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KMID : 0381920090390040301
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Korean Journal of Microscopy
2009 Volume.39 No. 4 p.301 ~ p.309
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Effects of Estrogen Receptor Agonist on Morphology in the Female Mouse Reproductive Organs
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Lee Eun-Jung
Han Ji-Yeon
Cho Hyun-Wook
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Abstract
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Estrogens induce pronounced structural and functional changes in male and female reproductive system, but the exact mechanisms of estrogen are not fully understood. In relation to estrogen’s function, the present study was designed to identify effects of estrogen receptor agonist, 4,4′,4′′- (4-propyl-[1H]-pyrazole-1,3,5-triyl)tris phenol (PPT) in the reproductive organ of the female mouse. The PPT was subcutaneously given to adult female mice at a weekly dosage of 3 mg in a volume 0.06 mL of vehicle for 3, 5 or 8 weeks whereas controls received weekly injections of the castor oil vehicle. Effects of PPT on reproductive organs were analyzed using a light microscope. PPT induced decreases of body, ovary and adipose tissue weights with experimental time. Ovary diameter of PPT treatment group was reduced as compared with control group. The number of Graffian follicle and corpus luteum was reduced in PPT treatment group. The luminal diameter of uterus was increased in relation with decrease of myometrium and endometrium height by PPT administration. The number of uterine glands was decreased by PPT treatment. These data indicate that PPT treatment induced morphological change of female reproductive organs resulting in alteration of fertility.
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KEYWORD
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Agonist, Estrogen receptor, Mouse, Ovary, Uterus
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